CHOLINERGIC AGONISTS ANTAGONISTS-2.pdf - CHOLINERGIC AGONISTS and ANTAGONISTS(Anticholinergics Drug Class Cholinergic Agonists TYPES 1

CHOLINERGIC AGONISTS ANTAGONISTS-2.pdf - CHOLINERGIC...

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1CHOLINERGIC AGONISTSandANTAGONISTS(Anticholinergics) Drug Class: Cholinergic Agonists TYPES:1) DIRECT-ACTINGStimulate the receptors directly2) INDIRECT-ACTINGDo not act on receptors; instead, they inhibit or inactivate the enzyme cholinesterase to allow for the accumulation of acetylcholine at the receptor siteKevin J Walgamotte, PharmD, BCNP, PRS.
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2Drug Class: Cholinergic Agonists TYPES OF INDIRECT ACTING:1) REVERISBLEPersists for hours2) IRREVERSIBLEExtremely potent agents because of their long-lasting effects. The enzyme cholinesterase must be regenerated before the drug effect diminishes and this may take days or weeks.ANTIDOTE---PRALIDOXIME CHLORIDE (PROTOPAM)Kevin J Walgamotte, PharmD, BCNP, PRS.Drug Class: Cholinergic Agonists Some EXAMPLES of generic (Brand)bethanechol chloride (Urecholine)metoclopramide HCL (Reglan)ambenonium chloride (Mytelase)edrophonium chloride (Tensilon)Kevin J Walgamotte, PharmD, BCNP, PRS.
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