Problem Set 3 F19 KEY.docx - Biochemistry 1 Problem Set 3 Fall 2019 Please explain your reasoning and show your calculations where appropriate Be sure

Problem Set 3 F19 KEY.docx - Biochemistry 1 Problem Set 3...

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Biochemistry 1, Problem Set 3, Fall 2019Please explain your reasoning, and show your calculations where appropriate. Be sureto staple your pages together, and write your name on the front page. The due date is Monday November 4that 5pm. Question 1 [10 points]You are a medical doctor investigating the sudden and unexpected illness of an 85-year old man in a nursing home. Blood analysis shows that the patient’s blood glucose is extremely low (0.2 mmol/L; the healthy range is 4-8 mmol/L). Your first suspicion is kidney failure. However, the blood analysis also shows an abnormally high insulin concentration (76,897 pmol/L; the healthy range is 60-120 pmol/L during fasting and up to 2,000 pmol/L after a meal). Intrigued, you order a C-peptide analysis, which shows that the patient has a low blood concentration of C-peptide (130 pmol/L; the healthy range is 260-1,000 pmol/L).Based on the finding of greatly increased insulin and suppressed C-peptide concentrations, you conclude that the patient has been administered a life-threatening insulin dose by the facility staff, and you alert the police.a.What is C-peptide, and how is it related to insulin production and secretion?b.Explain how elevated insulin and suppressed C-peptide is diagnostic for exogenous insulin administration(as opposed to a medical condition such as insulinoma). Proinsulin is converted to insulin by proteolytic cleavage that releases a short peptide, the C-peptide. So, C-peptide and insulin should increase and decrease in concentration together.A large increase in insulin without an increase in C-peptide indicates exogenous administration of insulin. If proinsulin and insulin are over-produced naturally (eg in insulinoma) then both insulin and C-peptide concentrations should increase.
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Question 2 [20 points]a.The affinity of oxygen binding to hemoglobin is affected by temperature. Do some research on the effectof temperature, and sketch oxygen binding curves for hemoglobin at normal (37 C) reduced, and increased temperatures.Binding curves should be right shifted as temperature increases. b.During exercise, actively metabolizing tissue (muscle) can have an elevated temperature. What are the physiological consequences of elevated temperature in the context of oxygen delivery to tissues?
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