Chapter_15_for_students(1).pptx - Chapter 15 Enzyme Regulation Essential Questions What are the properties of regulatory enzymes and what are the

Chapter_15_for_students(1).pptx - Chapter 15 Enzyme...

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Chapter 15 Enzyme Regulation
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Essential Questions What are the properties of regulatory enzymes, and what are the molecular mechanisms used to regulate enzymes? Two ways enzyme activity can be regulated are by changing the number of enzyme molecules or changing the activity of each molecule. Which one of these methods allows for a more rapid response and why? What is one advantage of having enzymatic rate display a sigmoidal response to changes in substrate concentration? Why might it be preferable for an enzyme to be produced as a zymogen rather than generating the active version of the enzyme directly? Suggest metabolic processes that could benefit from the use of zymogens. Why is feedback inhibition a useful way of regulating enzyme activity? 2
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Essential Questions Why might it be advantageous for allosteric inhibitors or effectors to be employed to regulate enzyme function? The activity of kinases can be reversibly modulated via intrasteric control involving regulatory subunits or domains. How can the inhibitory effect of a regulatory unit itself be modified? What are the advantages of employing an enzyme cascade to regulate activity of a target enzyme? Hemoglobin alters its affinity for oxygen depending on the acidity of its local environment as well as the concentration of carbon dioxide. What ramifications does this have for oxygen delivery to actively metabolizing tissues in the body? How do allosteric interactions allow fetal hemoglobin to exhibit a higher affinity for oxygen than the adult form? 3
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What Factors Influence Enzymatic Activity? Substrate availability 4
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What Factors Influence Enzymatic Activity? Cofactor availability 5
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What Factors Influence Enzymatic Activity? Product formation Actually in equilibrium after T 0 6
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What Factors Influence Enzymatic Activity?
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