181lec8.key-2.pdf - Psych 181 Dr Anagnostaras Lecture 8 OPIATES Opium I Classes Opioids Opiates \u25cf alkaloids found in the opium poppy(Papaver

181lec8.key-2.pdf - Psych 181 Dr Anagnostaras Lecture 8...

This preview shows page 1 - 6 out of 20 pages.

OPIATES Psych 181: Dr. Anagnostaras Lecture 8 Opioids Opiates alkaloids found in the opium poppy (Papaver somniferum) [Gk. opion = “poppy juice”] Opioids compounds with opiate-like actions, including, but not confined to opiates (e.g., synthetic, endogenous opioids) Opium come from here I Classes . /0p# /0pio - limited - Include opiate & anything like morphine
Image of page 1
Types of opioids 1. Naturally- occurring opium sap from opium poppy Two major active alkaloids morphine codeine . Opium itself or ingredients can get out of it Main : Morphine ( Io - so b) It store opium part of it go bad Before : use for pain killer Now : surgical anes . until it's extracted & stab lied 48 \ Dry up mucus s erection + Contain atropine t apobmine Raw opium : Paregoric Weak Before : cough deep . for kids . * Schedule 3
Image of page 2
25 x more potent than paregoric Morphine Morpheus (god of Dreams) -son of Hypnos ~ 10% of opium by weight HO O OH N CH 3 H Morphine Codeine methylmorphine ~ 0.5% of opium * Schedule I - Oldest - Naturally occurring - Naturally occurring A Opioid : treat pain * Side effects : sleepy ness , motor in c . Put kids to sleep ( Pharmacokinetics
Image of page 3
2. Semi-synthetics 2. Semi-synthetics Heroin diacetylmorphine addition of two acetyl groups to morphine ~ 10x more potent than morphine pharmacological effect usually thought to be identical to morphine in brain: heroin > morphine (new data suggest morphine and heroin may have different actions; 1999) 2. Semi-synthetic analgesics Hydromorphone (Dilaudid) Hydrocodone (Lortab, Vicodin) Oxycodone (Percodan, Percocet, Oxycontin) Once heroin gets in the brain it becomes morphine just get in FASTER than morphine * Schedule I Gone countries ) Diamorphine : surgical and . ( Europe ) µ Very slow I Heroin is Morphine - - More lipid sdulahile less lipid Sol . Get in brain much faster tapered : Big factor on how addictive the drugs describe dmginthevs . Treatcanarpainn Very potent . O - tweak potent a New , most popular treat pain well , among doctors to not produce moderate severe pain nausea , . . . A why popular ? * Best side effect profile More available Become drug abuse .
Image of page 4
3. Synthetics Phenylpiperidines Fentanyl “china white” Carfentanil (Wildnil®) Meperidine (Demerol®) (MPPP) Methadone & Congeners Methadone (Dolophine®) Propoxyphene (Darvon®) Benzomorphans Pentazocine (Talwin®) N CH 3 CH 2 C O O CH 3 Pethidine (Meperidine) N H (CH 3 ) 2 Methadone CH 2 C O CH 3 H 3 C H Percodan = oxycodone Most popular way to desc . oxycodone ( w/ aspirin ) Drugs that made in LAB . STRONGEST . Use in medicine & }→ aoodsignettedsisfterortoatnens ! Stronger than heroin Commercial large animal @ @ no longer strength m f ? in market can turn into vapor & spray into places ( Moscow ) .
Image of page 5
Image of page 6

You've reached the end of your free preview.

Want to read all 20 pages?

  • Summer '19

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes
A+ icon
Ask Expert Tutors