Bio Paper - the first treatment that targets immune cells...

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Rheumatoid Arthritis is an autoimmune disorder in which the afflicted individual’s immune system attacks their joints. Signs that one with this disorder may notice include inflammation and swelling of many joints at the same time. Pain and stiffness is usually felt in the morning and the pain will slowly start to ease as the day goes on and the joints are used more and more. Rheumatoid Arthritis may also cause deformation of the hands or other body parts if left untreated. The article I read was about a new treatment for Rheumatoid Arthritis that has recently been passed by the FDA. Rituxan, an antibody, combined with methotrexate has been shown to alleviate some signs and symptoms of adults suffering from this disorder. This treatment is being used to help those that have not responded well to the standard tumor necrosis factor antagonist therapies that are commonly used. This new antibody is
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Unformatted text preview: the first treatment that targets immune cells called CD20-positive B-cells. These B-cells are thought to affect the initiation and development of the disorder. The FDA used a random, double-blind, placebo controlled study to aid in its decision to approve the new antibody. The adverse side affects observed by patients that were exposed to Rituxan for 8 years were said to be similar to patients suffering from non-Hodgkin’s lymphoma. Common side effects noted during the clinical trials consisted of mostly infections and infusion reactions. In conclusion, the new treatment Rituxan is an important treatment to help those suffering from Rheumatoid Arthritis. It seems to safely lower the amount of bad B-cells while leaving the cells one needs such as stem cells and plasma cells unharmed. This new treatment may also help combat other autoimmune diseases in the future....
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This note was uploaded on 04/02/2008 for the course BIOL 055 taught by Professor Wallace,kathleen during the Spring '07 term at Pennsylvania State University, University Park.

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