Pharmacology Final.docx - Pharmacology Final Pharmacodynamics and Pharmacokinetics-Pharmacodynamics interactions between living organisms and foreign

Pharmacology Final.docx - Pharmacology Final...

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Pharmacology Final Pharmacodynamics and Pharmacokinetics - Pharmacodynamics- interactions between living organisms and foreign chemicals - Pharmacokinetics - study of absorption, distribution, metabolism (biotransformation), and excretion of drugs A. Effect of drug toxicity Primary Actions a. Overdose; extension of the desired effect Secondary Actions b. Undesired effects produced in addition to the pharmacologic effect Hypersensitivity Reactions c. Excessive response to primary or secondary effect of drug Signs and Symptoms of Organ Toxicity -CNS – altered LOC -Eyes- ocular damage -Ear- auditory damage, tinnitus -Mouth- Stomatitis, mucous membranes -Skin- hives, rash -Liver- fever, nausea, JAUNDICE, tea colored urine -Kidney- change in urinary pattern, increased BUN and creatinine (renal function test) -Bone marrow suppression – blood dyscrasia -Tetrogenicity Laboratory Testing ALT/AST – Liver function test BUN- Kidney function test Allergic Reactions Anaphylactic Reaction- constricting bronchi, hives, rash, increased BP Cytotoxic Reaction- antibodies attack antigens in blood, CBC, liver function test Serum Sickness Reaction- antibodies in blood damage various tissues, swollen lymph nodes, fever Delayed Allergic Reaction- antibodies bound to WBC, rash hives, swollen join ts Principles of Anti-Microbial Therapy 1. Bacteriostatic vs Bacteriocidal -Bacteriocidial- kill the cell -Bacteriostatic- prevent reproduction of the cell 2. Principles of Culture and Sensitivity -Culture- identification of pathogen -Sensitivity- identifies pathogen and appropriate drug for treatment 3. Indications and Uses
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Decrease the population of the invading bacteria to a point where the human immune system can effectively deal with the invader 4. PENICILLIN Core Drug Knowledge bactericidal, interfere with bacterial cell wall Adverse Effects- GI tract, nausea, vomiting, diarrhea Core Patient Variable Health Teaching & Nursing Intervention Asses RESPIRATORY function, abdominal and renal function, C&S Complete full course of antibiotics 5. ISONIAZID Core Drug Knowledge - antimycobacterial, kills TB and Leprosy Adverse Effect - peripheral neuropathy Core Patient Variable Nursing Intervention CNS dysfunction, respiratory renal and hepatic function test, Culture and sensitivity test Give vitamin B6 6. CLOTRIMAZOLE Core Drug Knowledge - Azoles / antifungal Indications and Uses - binds to sterols and can cause cell death, inhibit glucan synthesis used to treat fungal infection Tetrogenic Antiinflammatory Drug and Pain Medications 7. ASPIRIN- Treats inflammatory conditions, anti-inflammatory, anti-pyretic, anti-thrombotic, anti- analgesic Core Drug Knowledge – prevents conversion of arachidonic acid to prostaglandin - Contraindication and Precaution bleeding disorders, skin lesions, impaired renal function SALICYLISM- 20-25G DOSE IN ADULT and 4G in children SSx: hyperpnea, tachypnea, hemorrhage, excitement, confusion, pulmonary edema
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- Adverse Effect BLEEDING, ringing in the ears, tinnitus Petechiae
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  • Fall '19
  • Mark Daco

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