ps5key - Answea Kai Genome Sciences 351 Spring 2009 Mam...

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Unformatted text preview: Answea Kai Genome Sciences 351, Spring 2009 Mam pvt-q may mile on ‘h-hs #:66th ProblcmSetfis Birt— ME ME. ram-me: cochms mm DueMondayMayl8 Haas cWKEo we, 1) Southern African p0pulations have greater genetic diversity than other human populations. Explain this finding in terms of human migrations. AFeicAN "POPULA‘DONS ARE OLD AND HAVE HA-D 771E MosT TIME Fok THEIR, athOMfi-S 't"3 ‘Du/EikzstF‘f. EACH GEuEkk-“DN cA-H numpuea W thA-TtON- Ar: Mes pquuvnofib WE MKW’l‘E/D lat-Ho Baa-UH mew éfiaéflAW‘nL ?0PULA'S\ON5 7111?: Tom 5085515 5? Mall-E cum-nab (pauaflc. VM\A'HON wk’m W. WE Bawri ‘Rwubwb. $674953 ND Him/a W 0355 ’DME Tb wmgfl mu WE 0,961 um. Wick-N (Er-EMOTYPES.H1=NOE Wt M V—oioummovs CahJ‘l'thE T” M“: MAE Didges‘TY W M1 W 2) Three mutations occur simultaneously' in a large bat colony. The first mutation confers more sensitive hearing, which helps with echolocrttion. Bats with the second mutation have an extra nose wrinkle, which does not seem to change their sense of smell or ability to communicate. The last mutation causes bats to tremor slightly, interfering with their smooth quick flight. Plot the expected comparative allele frequencies ofthese new mutations over 200 generations. Label each allele frequency curve clearly. MWNN \ MUTMWN Z wmnon 3 «A UK ii a 3 4 $1 “3 cc 0 QENEKATNJNS 2cm MMON l— WEAR-6 Tb BE. MJAHMW Art-JD wt» “new WOREA-bE Dfl 'TlME Mmmn 7.- APPEMA Hat/MAL MID 1T5 mawci $5 WEE Ween/kl :WW—EWOMG no. Dew—emce— MmrtoNgt HPEAW: Tb BE HARMFUL. lbw: um. crew Dacia/+512 wee ‘nME 3) Rarely individuals are found who have inherited both copies of an autosome from one parent and none from the other. This can be explained by nondisjunction events happening during the formation ofthe gametes in each parent, one leading to loss of both copies and the other leading to tWO copies. The result is an individual with the expected two copies ofthe autosome, but with both copies coming from one parent. For the case in which a child has two copies of chromosome l2 from the father (one each from the father's mother and the father's father) and no copies from his mother draw the events in the paternal meiosis that would lead to the two copies of chromosome 12 in the sperm. NontsSwdmvN We? t-Hrta M250 m wiosus 1 mama. («+0.11 rimmi— OWL anti 0F Wfi .._9 ---—-———-v Hm - UtSISvauM h H mm 699 Mr Nth meme; M3- MI?— '9 4) Copies of mitochondrial DNA sequences are more abundant in ancient human remains (bones in particular) than are c0pies of nuclear DNA and are thus a popular target for analysis. Also a more variable segment of the mitochondrial sequence is flanked by two highly conserved segments. The polymerase chain reaction (PCR) is used to amplify the segment and the sequence of the variable part can then be used to position the specimen on the mitochondrial tree. The conserved portion is important because it can be recognized across all individuals by the two primers that are essential for PC R to work. Diagram this region of mitochondrial DNA showing where PCR primers will bind and the amplified region. Explain why it is important that conserved segments are on both PINMEAF sides ofthe variable segment. 1% a PM? ”N“, we answer: 6mm RO-E mvmmr FOL A Few REA‘JM') “so “Macao ,nrey comm are QEGWH 0F SIR/$5255? summer Wm US TO caesium MHF‘I Dv‘R Mm VAtztABLE a first 4w: amveo so 'wE £4ch TH'E SeaueNLE I 3:40 ”rt-E MA a” 0041 was. YP-lMEtLK \ 'TORVN t- M Ode-ll. HE car-sir Wr mm mo ”ME: \lfi-LKABLE. Ramon W—‘fl _ \ AMPLlFtED Rag-”N i BEWbE ’m-zb beenJENcE w» «(H Ftom PEZaoN TD i’aasm so we VbMEfls Mlb'H'l‘ roar BIND maPtuemw In em. swPoEs BY VLMWIT THEM :w-m: memo sewn we cabsElN fins WZOSLEM, ...
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