ps6 - Genome Sciences 351 Spring 2009 Problem Set#6 Due...

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Genome Sciences 351, Spring 2009 Problem Set #6 Due Wednesday May 27 1) On average, what percentage of genetic information do first cousins share? Show your reasoning. 2) In a twin study investigating the heritability of thoughtful forehead wrinkling (TFW), monzygotic twins have a concordance of 80% and dizygotic twins have a concordance of 40%. Based on this information does TFW have a heritable component? Explain your answer. 3a) Chadwick is studies the genetics of myopia, a complex trait. He has genotyped 5 people with myopia, and 5 without at 4 SNPs. Which of the SNPs is most likely to be linked to the trait? Which allele of the SNP? Explain. myopic non-myopic rs1 T G G G G G G G G G rs2 C A A C C A C A C A rs3 A A A T A T A T T T rs4 A G A A A A G G A A
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3b) Chadwick was pleased with his findings and wanted to follow up with another study with a larger sample size (number of individuals). He typed another 4 SNPs in 5 myopic African Americans (AA), 5 non-myopic African Americans, 5 myopic Latinos
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This note was uploaded on 06/14/2009 for the course GENOM 351 taught by Professor Waterson during the Spring '09 term at University of Washington.

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ps6 - Genome Sciences 351 Spring 2009 Problem Set#6 Due...

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