ANTH 1001 2-19

ANTH 1001 2-19 - ANT H 1001 2-19 Red blood cell variants...

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Unformatted text preview: ANT H 1001 2-19 Red blood cell variants and malaria. I. Sickle cell a. What is sickle cell? Cells that are sickle shaped; they form clumps in blood flow b. Malaria c. Relationship between sickle cell allele and malaria i. Evidence 1. Geographical correlation between the distributions of sickle cell allele and malaria 2. Clinical and experimental studies show that heterozygotes for the sickle cell allele have lower rates of malarial parasitic infestation than individuals with normal hemoglobin (individuals homozygous for normal hemoglobin) ii. Why is heterozygosity for the sickle cell allele advantageous in a malarial environment? 1. Heterozygotes for sickle cell show selective destruction of red blood cells (RBCs). 2. Uninfected RBCs do not sickle; these cells deliver adequate amount of oxygen to the tissues. RBCs infected with malarial parasites do sickle; this sickling provides a lethal environment--kills the parasite....
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ANTH 1001 2-19 - ANT H 1001 2-19 Red blood cell variants...

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