lecture 7 sp 09 given - Lecture 7 L t Chemistry 310N...

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Lecture 7 Chemistry 310N Organic Chemistry II for Prehealth Professionals Unique number: 53185 Tu,Th 12:30-2:00 pm, Welch 2.224 rofessor: Jonathan Sessler Ph D Professor: Jonathan Sessler, Ph.D. sessler@mail.utexas.edu Notes: 13 C NMR spectroscopy, although in the book, will not be on Exam I Exam 1 will cover chapters 12 and 13 in detail and chapter 14 in cursory fashion. It is Thursday in class! Dr. Sessler’s office hours in Wel. 3.422 2:00-3:30 pm today. Homework Key has been posted early; please “enjoy” it!!
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romatic Systems Aromatic Systems Sometimes easy but often complex because of multiple splittings he rule of next door neighbors being the only ones that The rule of next door neighbors being the only ones that lead to splitting breaks down. Look for symmetry; count number of hydrogen atoms, and keep an eye out for classic, so-called AB splitting pattern that arises from two adjacent ( ortho ) protons in different hemical and magnetic environments chemical and magnetic environments.
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terpreting NMR Spectra Interpreting NMR Spectra • Spectral Problem; molecular formula C 7 H 14 O. Taken From Book. Come to Office Hours if You Need Help Figuring This One Out !!
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3 MR Spectroscopy 13 C-NMR Spectroscopy • Each nonequivalent 13 C gives a different signal –A 13 C signal is split by the 1 H bonded to it according to the ( n + 1) rule. – Coupling constants of 100-250 Hz are common, which eans that there is often significant overlap between signals means that there is often significant overlap between signals, and splitting patterns can be very difficult to determine. he most common mode of operation of a 13 MR The most common mode of operation of a C-NMR spectrometer is a proton-decoupled mode.
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3 MR Spectroscopy 13 C-NMR Spectroscopy • In a proton-decoupled mode, a sample is irradiated with two different radiofrequencies, 3 – one to excite all 13 C nuclei. – a second broad spectrum of frequencies to cause all rotons in the molecule to undergo rapid transitions protons in the molecule to undergo rapid transitions between their nuclear spin states. n the time scale of a 13 MR spectrum each proton On the time scale of a C-NMR spectrum, each proton is in an average or effectively constant nuclear spin state, with the result that 1 H- 13 C spin-spin interactions are not observed; they are decoupled.
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3 MR Spectroscopy 13 C-NMR Spectroscopy – Proton-decoupled 13 C-NMR spectrum of 1-bromobutane.
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hemical Shift 3 MR Chemical Shift - 13 C-NMR 13 C-NMR chemical shifts of representative groups.
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hemical Shift 3 MR Chemical Shift - 13 C-NMR Type of Carbon Chemical Shift ( δ ) δ ) Carbon R C H 3 R C H 2 R R 3 C H R C 110-160 20-60 15-55 10-40 R C H 2 Br R C H 2 I O R C OR O 0-40 160 - 180 25-65 R C H 2 Cl R 3 C OH R C NR 2 O 165 - 180 40-80 35-80 R 2 C =CR 2 R C CR R 3 C R C H, R C R OO RC C 165 - 185 180 - 215 40-80 65-85 100-150
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uclear Magnetic Nuclear Magnetic esonance Resonance End Chapter 13
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hapter 14 Chapter 14 Mass Spectrometry
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ass Spectrometry (MS) Mass Spectrometry (MS) An analytical technique for measuring the mass-to- charge ratio ( m/z ) of ions in the gas phase.
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This note was uploaded on 06/15/2009 for the course CH 53185 taught by Professor Sessler during the Spring '09 term at University of Texas at Austin.

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lecture 7 sp 09 given - Lecture 7 L t Chemistry 310N...

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