vitamin k review - Vitamin K Synthetic form-menadione o o...

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Vitamin K Synthetic form-menadione o Toxic to humans o Use for large animals that can metabolize it Absorption o Synthetic more easily absorbed o All fat soluble vitamins absorbed::: Pancrease secretes bile into duodenum and emulsifies fat, micelles incorp. Micelles get into enterocyte-intest cell CCK-leaves through lymph system Tissues take off some of fat so by time get to liver have cck remanant packed w/ fat soluble vitamins--- liver Fat malabsorption disease o Risk for fat sol vit. Def Ldl, vldl, etc is how it gets to tissues Storage o Liver predominant as menaquinone Function o Required for blood clotting and bone formation o Glu- gla o POST TRANSLATIONAL MODIFICATION-just adding co2
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o Need: Dihydroquinone-k in active form Co2 O2 Carboxylase Dihydroquinone becomes epoxide; oxygenated; so must regenerate 1. Epoxide-quinone 2. Quinone-dihydroquinone Warfarin-competes with vit. K for reductases; so cant generate dihydroquinone-this is how it thins your blood
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vitamin k review - Vitamin K Synthetic form-menadione o o...

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