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Unformatted text preview: I. Chromium I I. Iodine a. Thyroid follicles with colloid b. Thyroperoxidase-adds iodine to c. Glutathione peroxidase d. Thyroperoxidase e. Rt3-inactive-doesn’t leave thyroid gland f. In blood i. Thyroxine binding ii. Albumin iii. Trans iv. Free hormone is only hormonally active g. Prehormone-absorbed by cells i. T3-active because enters nucleus and has effects at dna level ii. Enzymes-deiodinases 1. T4-t3 h. Goiter i. T4 under tight hormonal control ii. Drop blood tw iii. Release hormone to tell pit to secrete tsh iv. Tells thyroid to make more t4 v. Enough t4-tells pit to stop making tsh vi. Deficient 1. More tsh made 2. Goiter=hyperplasia 3. Trap as much iodine as can i. Status i. Urine-cerric-cerous 1. More urine: deficient ii. I I I. Selenium IV. Zinc a. Transport proteins i. Albumin-major blood zinc transport protein b. Zinc metabolism i. Enterocyte 1. Megadoses of zinc are absorbed by paracellular transport ii. Tissues 1. Zinc supplementation increases metallothionein expression...
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This note was uploaded on 06/16/2009 for the course HUN 4221 taught by Professor Shellnut during the Spring '09 term at University of Florida.
- Spring '09