iron part 1 - IRON Essential transition metal element o o...

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IRON Essential transition metal element o Outer shell is incomplete so it can ACCEPT/DONATE ELECTRONS to assume multiple valence states o MOSTLY USED FOR REDOX Fe2+ and Fe3+ become complexed with six water molecules o Their solubility depends on the pH of the solution** Fe2+ o More soluble, and more bioavailable o FERROUS, reduced o pH 6.5=precipitates Fe3+ o pH 2.5=precipitates o FERRIC, OXIDIZED Location in body o Hemoglobin, myoglobin Binding and transport of O2 Hemoglobin has 4 globin subunits with a heme group containing iron Hemoglobin contains 2/3 body iron in RBCS*** o Transferrin Transports iron o Ferritin/Hemosiderin Iron storage protein Iron Metabolism
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Dietary absorption o Only about 1-2mg of Fe from duodenum Bound to transferring bone marrow Bone marrow o Erythopoesis-where RBC synthesized o Live about 120 days and need about 24 mg of Fe in order to be made o Therefore, we absorb only 1-2 mg of dietary iron and more of Fe in RBCs is from Liver o Stores a lot of Fe complexed in HEME RES- reticuleondeothelial system o 22mg of Fe is recycled from RES and is bound to TRANSFERRIN and most of it is recycled back to the bone marrow Macrophages in the liver(kupffer cells), spleen, and bone marrow eat old (senescent) RBCs and recycle Fe. Iron Overload o Don’t have a mechanism to excrete Fe as we do zinc, so it is easy to have overload Heme Fe vs. Nonheme Fe o Heme Locked in and better protected Sources: meat in hemoglobin, myoglobin, cytochromes We eat the muscle of the meat and some of the blood Highly bioavailable o Nonheme Fe Raisin bran, oatmeal, soybeans Souces: can be organic chelates Ex: ferric citrate, ferrous fumarate
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Constituents of biological molecules o Iron sulfar enzymes o Ferritin Found in plants and meat Relatively poorly bioavailable o Very susceptible to other things in diet
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This note was uploaded on 06/16/2009 for the course HUN 4221 taught by Professor Shellnut during the Spring '09 term at University of Florida.

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iron part 1 - IRON Essential transition metal element o o...

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