lower gi tract - Diseases/Disorders of the Intestinal Tract...

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1 Gail P. A. Kauwell, PhD, RD, LDN HUN 4446 - Spring 2009 Diseases/Disorders of the Intestinal Tract Diseases of the Intestinal Tract • Compare normal gastrointestinal (GI) structure and function to the changes that occur in diseases/disorders of the lower GI tract. • Describe the etiology, symptoms, clinical findings and pathophysiology associated with diseases/disorders of the lower GI tract. • Describe the diagnostic tests/procedures and intervention strategies (i.e., medical, surgical, pharmacologic, nutritional) used to treat/manage diseases/disorders of the lower GI tract. • Differentiate among diseases/disorders of the lower GI tract based on risk factors, etiology, symptoms, clinical findings, laboratory data, diagnostic tests, pathophysiology and medical/surgical, pharmacological and nutritional management. Objectives • Relate the signs, symptoms, clinical findings, laboratory data, diagnostic tests, and medical, surgical, pharmacologic and nutritional interventions to the underlying pathophysiology of diseases/disorders of the lower GI tract. • Interpret the results of laboratory/diagnostic tests. • Recommend appropriate nutritional management for patients with diseases/disorders of the lower GI tract based on information presented in case studies. • Select appropriate medical, pharmacologic and/or surgical interventions for patients with diseases/disorders of the lower GI tract based on information presented in case studies. Objectives
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2 Gail P. A. Kauwell, PhD, RD, LDN HUN 4446 - Spring 2009 Diseases/Disorders of the Intestinal Tract Celiac Disease Gluten-sensitive enteropathy: • gluten sensitive enteropathy • celiac sprue • nontropical sprue Pathogenesis: • genetic predisposition • immunologic component -T-cell mediated - autoimmune intestinal enteropathy • environmental trigger - ingestion of gluten-containing grains/foods Celiac Disease Effects of autoimmune response: • intestinal damage • disturbed nutrient absorption & transport • extraintestinal effects Celiac disease
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3 Gail P. A. Kauwell, PhD, RD, LDN HUN 4446 - Spring 2009 Diseases/Disorders of the Intestinal Tract Patients with classic GI symptoms only represent the tip of the iceberg Source: The Children’s Digestive Health and Nutrition Foundation, November 2008 (http://www.celiachealth.org). Extra-intestinal effects of CD depression peripheral neuropathy irritability Extra-intestinal effects of CD muscle weakness bone loss
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Gail P. A. Kauwell, PhD, RD, LDN HUN 4446 - Spring 2009 Diseases/Disorders of the Intestinal Tract Extra-intestinal effects of CD unexplained anemia skin rashes dermatitis herpitiformis reproductive problems Extra-intestinal effects: Dermatitis Herpetiformis Source: The Children’s Digestive Health and Nutrition Foundation, November 2008 (http://www.celiachealth.org). Extra-intestinal effects of CD
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lower gi tract - Diseases/Disorders of the Intestinal Tract...

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