Lecture%203 - Lecture 3 Outline transport cont'd Active...

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Lecture 3 9/30/04 Outline: transport, cont’d: Active Transport, primary, secondary, Nervous system: neurons + glia, Membrane Potentials, Diffusion Potentials, Resting Potentials, Graded Potentials, Action Potentials Active Transport -net transport against the concentration gradient (from low to high concentration gradient -requires the input of energy, in the form of ATP -ATP=adenosine triphosphate (3 energy-rich bonds) 1)Primary active transport-in all cells in the plasma membrane i.e. ion pumps -uses energy directly Example: Na+/K+ pump (similar to a battery charger) -converts the chemical energy of ATP into a Na+ gradient and a K+ gradient -ATP hydrolysis: ATP -> ADP + Pi -the energy from ATP hydrolysis pumps 3 Na+ out of the cell, and 2 K+ into the cell (forces movement against the concentration gradient) Example: Ca2+ pump -energy from ATP hydrolysis used to pump CA2+ out of the cell in to confine Ca2+ in the cell -Ca2+ pump=Ca2+ ATPase Example: H+ pumps -move H+ out of cell into the gastric fluid and makes it acidic, which inhibits gastric secretion in the stomach -the “purple pill” advertised on the market is called Nexium-inhibits H+ pumps -pumps do not use energy, they just turn it into another form 2) Secondary Active Transport-uses energy gained from the pump through ATP
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