image.jpg - EXERCISE TEN Histology of Muscle Tissue FIGURE 10.4 Structure of a skeletal mus cle fiber(continued c organization of thin and thick

image.jpg - EXERCISE TEN Histology of Muscle Tissue FIGURE...

This preview shows page 1 out of 1 page.

Image of page 1

You've reached the end of your free preview.

Want to read the whole page?

Unformatted text preview: EXERCISE TEN Histology of Muscle Tissue FIGURE 10.4 Structure of a skeletal mus- cle fiber (continued). c) organization of thin and thick filaments in a sarcomere; d) electron micrograph of a arcomere (TEM X 64,000). I band A band H band Z line Titin (c) Zone of overlap M line Thin Thick filament filament Sarcomere I band A band H band Z line (d) Z line Zone of overlap M line Sarcomere CLINICAL CORRELATION causes several muscle proteins to become damaged and non- Duchenne's muscular dystrophy (DMD) is a genetic dis- functional. Most individuals afflicted with this disorder die by ease that is found almost exclusively in males. The disease, their late teens due to paralysis of the diaphragm and other which appears during early childhood, results in progressive de- respiratory muscles. terioration and weakness of skeletal muscles. The muscle fibers Recently, the gene responsible for the production of of individuals with DMD lack or have low amounts of the pro- tein dystrophin, which is typically attached to the inside surface dystrophin was identified on the X chromosome. Because DMD is a sex-linked disease, a woman can have one abnormal dys- of the sarcolemma, adjacent to the triads, Lack of this protein trophin gene and not be affected. This is because the defective causes muscle cell membranes to rupture easily and triggers a gene is "masked" by the normal gene on the second X chromo- rapid influx of calcium jons into the sarcoplasm In children with DMD, the prolonged period of high calcium levels disrupts some, She can, however, pass the disease on to her sons. Prenatal testing is now available to determine whether a woman the normal contraction and relaxation of muscle fibers and possesses a defective dystrophin gene....
View Full Document

  • Winter '08
  • Spranger

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask ( soon) You can ask (will expire )
Answers in as fast as 15 minutes
A+ icon
Ask Expert Tutors