Chapter 4 - Overview of Protein Structure and Function...

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1 proteins Overview of Protein Structure and Function (review Chapter 4) Proteins : at the heart of Cell Biology come in all shapes and sizes provide structure to the cell do the work of a cell (enzymes) send & store information Protein Structure Common features : basic amino acids peptide backbone secondary structure binding principles Unique features : tertiary structure protein-protein interactions (multimers) ligand/co-factor binding regulation In theory: A four amino acid protein = 160,000 possibilities [20 4 ] and most proteins are 100-500 amino acids long Toooooo many! There are constraints! Lots of combinations are NOT possible. This allows for general considerations of protein structure and function
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2 Basic unit = amino acid common to all proteins • Side chain (R group) have different properties • Provide reactive groups - structure and function Amino acids are joined together using a common bond – peptide bond
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3 04_02_polypeptide back.jpg In cell this is done sequentially. Amino acids Properties of amino acid side chains provide unique functions dictated by their structure and chemistry.
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4 Bond types Protein have characteristic 3D structure: folding seeks lowest energy state – a physical property
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Chapter 4 - Overview of Protein Structure and Function...

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