{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Chapter 21 lecture - Cells Extracellular Matrix(ECM =...

Info icon This preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Cells + Extracellular Matrix (ECM) = TISSUES Four types of tissue: nerve muscle epithelial connective Connective Tissue amt ECM >> cells variable carries mechanical load - strength resilient, shock proof = cartilage soft/transparent - vitrous in eye tough/flexible - skin hard/dense = bone Property of ct depends on amount and type of collagen
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 Collagen made by fibroblasts ~ 20 different kinds ~25% total mass of a mammal even more so in bone / tendon collagen made inside fibroblasts and secreted out as self-assemble a long TRIPLE helix - gly every third aa
Image of page 2
3 now can go end to end to create large fiber outside of cell cells = fibroblasts/osteoblasts organize the ECM cross-linking fibers allows increased strength if absent = famous elastic man 1. plywood like arrangement of collagen in skin increases strength also see immature bone, cornea 2. can secrete collagenases to help organize it after secreted - crawl along fibers too E= secrease - into sheets/fibers E= matrix proteases - digest it away tendons - long parallel strands
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
4 Cell Adhere to ECM - Integrins
Image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern