Chapter 21 lecture - Cells + Extracellular Matrix (ECM) =...

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1 Cells + Extracellular Matrix (ECM) = TISSUES Four types of tissue: nerve muscle epithelial connective Connective Tissue amt ECM >> cells variable carries mechanical load - strength resilient, shock proof = cartilage soft/transparent - vitrous in eye tough/flexible - skin hard/dense = bone Property of ct depends on amount and type of collagen
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2 Collagen made by fibroblasts ~ 20 different kinds ~25% total mass of a mammal even more so in bone / tendon collagen made inside fibroblasts and secreted out as self-assemble a long TRIPLE helix - gly every third aa
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3 now can go end to end to create large fiber outside of cell cells = fibroblasts/osteoblasts organize the ECM cross-linking fibers allows increased strength if absent = famous elastic man 1. plywood like arrangement of collagen in skin increases strength also see immature bone, cornea 2. can secrete collagenases to help organize it after secreted - crawl along fibers too E= secrease - into sheets/fibers E= matrix proteases - digest it away tendons - long parallel strands
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4 Cell Adhere to ECM -
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Chapter 21 lecture - Cells + Extracellular Matrix (ECM) =...

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