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Chapter 16 lecture - Cell Communication Signal Transduction...

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1 Cell Communication Signal Transduction - conversion of one type of signal to another can consider it from a couple of view points: • chemical to electrical • electrical to chemical • chemical to chemical or from: • inside to outside • outside to inside ions What turns ON must turn OFF! Affector(s) Effector(s) Receptors feedback (+’ve or -’ve) extracellular_sig.jpg Affector(s) Effector(s) Receptors the combination dictates final effect including cell identity, survival, fitness
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2 General forms of “between cell” signaling in body include: + a fifth one not mentioned - “autocrine” self-regulation, feedback to self long & short range, very rapid, accurate long range (whole body) chemical signal short range chemical signal Very short range - intimate contact required Signal transduction: conversion of an extracellular signal to intracellular effects cascade can include chemical second messenger cascades protein-protein interactions (kinases and phosphatases) information processing effector function effect multiple cell processes ligand
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