Lieb_Prob_Set_6_key

Lieb_Prob_Set_6_key - BIOLOGY 202- LIEB KEY- Problem set 6...

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BIOLOGY 202- LIEB KEY- Problem set 6 Underlined terms are terms you should know. 1.) Assume that part of the way that a certain set of genes are regulated is by having binding sites of differential affinity in their promoters . Assume genes X, Y, and Z are all positively regulated by Bicoid , are all transcribed at the same level, but have non-overlapping patterns of expression . Gene X is most anterior , gene Z is most posterior , and gene Y is between them. Which gene would you expect to have the highest-affinity bicoid binding sites? Which would you expect to have moderate affinity sites, and which would you expect to have low affinity sites? Is another mechanism required to keep genes Y and Z from being expressed in the anterior? Explain your answers. The promoter of gene X will have the lowest-affinity bicoid binding sites. Therefore, it will respond only to the highest concentrations of bicoid. The promoter of gene Z will have the highest-affinity binding sites, so that it can respond to low levels of bicoid present towards the posterior. The promoter of gene Y will have binding sites of intermediate affinity. Note that at least one other mechanism of regulation is needed to keep genes Y and Z from being expressed in the X domain, and from Gene Z from being expressed in Y’s domain. This could be accomplished in a number of ways. One
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Lieb_Prob_Set_6_key - BIOLOGY 202- LIEB KEY- Problem set 6...

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