Hormone function.docx - Hormone function 2 ligands that bind to their respective intraor extracellular receptors Hormone secretion-Regulated through a

Hormone function.docx - Hormone function 2 ligands that...

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Hormone function - ligands that bind to their respective intra- or extracellular receptors. 2. Hormone secretion -Regulated through a negative feedback system. -When target cell response is achieved, feedback signals the hormone to decrease its output. 3. Water- Soluble Hormones - Catecholamines and Peptides -Free molecules - The only hormones that are circulating free are available for binding with receptors. - Active-form: Free circulating available to exert an effect. --Faster in moving - Plasma 1/2 life correlates directly to the % of protein binding 4. Lipid- Soluble Hormones - Steroids, thyroid hormones - Bound to plasma proteins. 5. Major sites of hormone degradation and excretion liver and kidneys 6. Negative Feedback DECREASE subsequent synthesis DECREASE secretion of hormone 7. Decrease in maximal responsiveness of hormone May be due to: - A decrease in # functional target cells - A decrease in # of receptor cells. - Limited concentration of an enzyme - Increase concentration of noncompetitive inhibitor 8. Decrease in hormonal sensitivity May be due to: -Decrease in # of hormone receptors
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9.Up-regulationlow hormone concentration induces the formation of more receptors per cell 11.Primary endocrine disorder-Alternation of the target gland/tissueexample: Thyroid 12.Secondary endocrine disorder-Alternation in the influencing tropic gland/tsexample: pituitary 13.Tertiary endocrine disorder 14.Normal endocrine physiology 15.Growth Hormone(Normal Functions)Anti-insulin effects: 17.Growth Hormone
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