Adrenergics Study Guide.docx - Adrenergic Receptors Alpha 1 Activation mainly used for vasodilation or mydriasis(dilation of the eyes Therapeutic

Adrenergics Study Guide.docx - Adrenergic Receptors Alpha 1...

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Adrenergic Receptors Alpha 1 Activation: mainly used for vasodilation or mydriasis (dilation of the eyes)Therapeutic ApplicationsHemostasis Nasal decongestion Adjunct to local anesthesia Elevation of blood pressure Mydriasis: dilation of the pupil Adverse Effects Hypertension Necrosis Bradycardia Alpha 2: activation inhibit NE release, not significant in the PNSIn the CNS alpha 2 can reduce sympathetic outflow to the heart and blood vessels & relieve severe pain Beta 1: all clinically relevant response at r/t the heart Therapeutic applicationsHeart Failure Shock Atrioventricular Heart block Cardiac arrest Increases kidney output and perfusion Adverse Effects Alters HR or rhythmAngina pectoris Beta 2: activation is limited to the lungs and the uterus Therapeutic Applications Asthma Delay in preterm labor Adverse Effects Hyperglycemia Tremor Dopamine: activation results in dilation of the renal vasculature Therapeutic Applications
Shock- in the prevention of renal failure & enhance cardiac performance by activating beta 1 receptors in the heartDopamine drug itself: Can affect alpha 1, but only at high doses- dose depended receptor. Low doses- stimulates dopamine receptor, mod: dopamine and beta 1, high: dopamine and alpha 1 Adrenergic Agonists Sympathomimetic, include naturally occurring and synthetic catecholayminesThree main effects: vasoconstriction, cardiac stimulation, bronchodilationAdditional effects: nasal and ophthalmic decongestantsClinical Use Vasoactive effects: cardiac arrest, hypotension, heart failure, shock, increase BP (neurogenic orthostatic or dialysis hypotension), with local anesthetics for prolonged effectsBronchodilation: asthma, acute allergic reactions

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