Name: ______________________________ UGAMyID: _______________ BCMB 3100 (Medlock) Fall 2005 Exam 1 (120 points) 1. (10 pt) (a) Draw the hydrogen bonding pattern that water forms with acetamide (CH2CONH2). (b) Describe hydrophobic interactions. 2. (15 points) The titration curve of Arginine is shown below. This amino acid has three ionizable side chains. Use the chart of pKa values, the titration curve, and the labeled points to answer the following questions. Titration curve of Arg0246810121400.511.522.533.5Equivalents of OH-pHa) Draw the species that predominate at 1, 1.5, and 2.5 equivalents of OH-. b) Calculate the pI of arginine? c) Consider only the side chain of arginine. What is the ratio of the deprotonated forms (the basic form) to the protonated form (acidic form) in a solution with a pH of 10.5? Use the Henderson-Hasselbalch equation.
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