Breast Cancer.pdf - NATIONAL CENTER FOR CASE STUDY TEACHING...

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NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCECase copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Originally published October 15, 2018. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work. Photo © Richard FIsher, cc by 2.0, <>.NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCEUsing Precision Medicine to Target Breast Cancer and the Cell Cycleby Kelsie M. Bernot, Telah A. Wingate, & Kiara D. Whitaker Department of Biology North Carolina A&T State University, Greensboro, NCKnow Your Enemy, Know Yourself:IntroductionLearning ObjectivesAfter completing this case study, you should be able to:Read and interpret breast cancer pathology results. Draw the phases of mitosis.Connect cell signaling to cell cycle regulation, and explain how dysregulation of those events can lead to cancer.Discuss how physicians use precision medicine to obtain genetic information about the individual’s tumor tissue to target treatment specific to that individual’s cancer.Discuss how physicians use precision medicine to obtain genetic information about the individual’s somatic, non-cancerous cells to make decisions about treatment. Define incidenceand mortality.Compare how health disparities impact patients’ and physicians’ abilities to know the enemy and know themselves in the United States and the world. Discuss the impact of ethnicity, age, geographic location and healthcare infrastructure on health disparities.VideosPlease preapre for our class meeting by watching the following videos and taking notes on the phases of mitosis.Video 1:Hasudungan, A. 2013. Cell cycle (mitosis). Running time: 9:52 min. <>.Video 2:BiologySpotTutors. 2012. Cell cycle checkpoints. Running time: 3:44 min. <>.After watching these two videos you should be able to: Describe the cell cycle and what happens at each phase: G0, G1, S, G2, M, and cytokinesis.Describe the three cell cycle checkpoints, what is being detected at each checkpoint, and what happens to the cell if it does not meet the requirements of the checkpoint.Next, watch the following:Video 3:Bozeman Science. 2014. Phases of mitosis. Running time: 10:41 min. <>.You should now also be able to:List the phases of mitosis in the order in which they occur and describe what happens in each phase.If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat. If you know neither the enemy nor yourself, you will succumb in every battle. —Sun Tzu, The Art of War
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCEPage 2“Know Your Enemy, Know Yourself” by Bernot, Wingate, & WhitakerPart I – Uh-oh

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