permasalahan preformulasi obat.docx - No 1 Permasalahan Laktosa yang mempunyai buruk sehingga Solusi kompresibilitas Laktosa diganti dengan avicel 101

permasalahan preformulasi obat.docx - No 1 Permasalahan...

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No . Permasalahan Solusi 1. Laktosa mempunyai kompresibilitas yang buruk sehingga friabilitasnya buruk. Laktosa diganti dengan avicel 101 2. PVP sifatnya higroskopis sehingga mengakibatkan tablet menjadi basah Masalah bisa diatasi dengan merubah kadar PVP menjadi 2% 3. Avicel cenderung membentuk muatan listrik dan meningkatkan kandungan lembab serta dapat meyebabkan pemisahan saat granulasi. Mengeringkan avicel untuk menghilangkan lembab 4. Sifat hidrofobik dari lubrikan akan mempengaruhi disintegrasi dan disolusi tablet. lubrikan dapat dikombinasikan dengan glidan dengan perbandingan 1:2. Formulasi Baru R/ Acetaminophen 300 mg PVP 10 mg (2%) Avicel 101 75 mg (15%)
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