Antipsychotic Medications.docx - Antipsychotic Medications First Generation(Typical Conventional Agents[1950\u2019s Low Potency Generic Chlorpromazine

Antipsychotic Medications.docx - Antipsychotic Medications...

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Antipsychotic Medications First Generation (Typical, Conventional) Agents [1950’s] Low Potency Generic Brand Dose Half-life Labs Chlorpromazine* Thorazine® 25 – 800 mg/d unknown FBS / FLP Thioridazine Mellaril® 150 – 800 mg/d unknown FBS / FLP *Liquid and IM formulation Common Side Effects of Low Potency Agents Sedation: Histamine Blockade Anticholinergic- (dry mouth, constipation, blurred vision, urinary retention, confusion): Muscarinic Adrenergic blockade Hypotension: Adrenergic blockade Extrapyramidal side effects (EPS) but less vs high potency agents High Potency, High EPS, Low Anticholinergic Effects Generic Brand Dose Half-life Pimozide Orap® 0.5 – 9 mg/d 54 to 168 hr Haloperidol* Haldol® 1 – 30 mg/d 12 to 37 hr Fluphenazine * Prolixin® 0.5 – 40 mg/d 14 to 15 hr Thiothixene* Navane® 2 – 30 mg/d 3 to 34 hr Trifluoperazine Stelazine® 1 – 40 mg/d unknown Perphenazine Trilafon® 8 – 64 mg/d unknown Loxapine Loxitane® 20 – 250 mg/d 3 to 4 hr; IM 12 hr *Liquid and IM formulation Depot Formulation: Haloperidol Haldol Decanoate® IM 50 – 100 mg Every 4 weeks Fluphenazine Prolixin Decanoate® IM 12.5 – 100 mg Every 2 - 4weeks Common Side Effects of High Potency Agents
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