Exam1 - Starsha McGrath October 23, 2007 MIC419H...

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Starsha McGrath October 23, 2007 MIC419H (Immunology) Dr. Decker Exam 1 1. Coxsackievirus B Innate immunity response: Virus infects cell Induction of interferon- α Natural Killer (NK) cell cytotoxicity activated (catatonic T lymphocytes lack T- cell receptors to recognize antigens) Th1 cell devolvement stimulated T-cells produce TNF- α TNF- α signals liver to make acute phase proteins Adaptive immunity response: Th1 cells make interferon- γ Interferon- γ blocks the growth of Th2 cells Antigen specific T cells proliferate and differentiate Antibodies and effector T cells are dispersed through the circulation and back into the infected sites 2. Developing lymphocytes whose receptors interact weakly with self antigens or that bind self antigens in a particular way receive a signal that enables them to survive. This is called positive selection. Negative selection is when lymphocytes whose receptors bind strongly to self antigens that receive signals that lead to their death. During development of lymphocytes, receptor gene segments undergo somatic recombination to generate intact V-region exons that encode the V
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Exam1 - Starsha McGrath October 23, 2007 MIC419H...

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