Mechanisms

Mechanisms - Hepatitis C virus(HCV is the major causative...

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Hepatitis C virus (HCV) is the major causative agent of chronic non-A, non-B hepatitis. The life cycle of HCV is largely unknown because a reliable culture system has not yet been established. HCV presumably binds to specific receptor(s) and enters cells through endocytosis, as do other members of the Flaviviridae family of viruses . The viral genome is translated into a precursor polyprotein after uncoating, and viral RNA is synthesized by a virus-encoded polymerase complex. Progeny viral particles are released into the luminal side of the endoplasmic reticulum and secreted from the cell after passage through the Golgi apparatus. (Moriishi, K. Matsurra, Y. 2003). Acute hepatitis C is usually subclinical. It has been reported that spotty necrosis/degeneration of hepatocytes and mixed inflammatory infiltrates in lobular parenchyma and portal tracts in acute hepatitis C. Dense lymphoid aggregates in the portal tracts, inflammatory bile duct damage, and microvesicular steatosis were also found. Diepolder showed
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This note was uploaded on 04/02/2008 for the course MIC 419 taught by Professor Decker during the Fall '07 term at Arizona.

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Mechanisms - Hepatitis C virus(HCV is the major causative...

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