7 - Molecular Cell Biology 32 Professor Andrew Wurmser...

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Molecular Cell Biology 32 Professor Andrew Wurmser 9/18/07 Lecture 7 Sharing or distribution of lecture notes, or sharing of your subscription, is ILLEGAL and will be prosecuted. Our non-profit, student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. Sharing or copying these notes is illegal and could end note taking for this course ANNOUNCEMENTS Slides were not put up until late last night because the site was overloaded. The slides that are up right now will be updated. I will put a copy of the 2005 exam on the resource section of bSpace. Keep in mind that this exam was created by a different professor, although there is a high degree of overlap between the two classes. Don’t freak out if there are things that we didn’t discuss on this practice test. The midterm will be multiple choice and true/false. LECTURE Review We will review calcium ion signaling and synaptotagnin. We will talk about signaling in the context of potentiation of long term memory. We talked about synaptic vesicles at the terminal button and that they don’t undergo spontaneous fusion with the plasma membrane, but remain docked. Cell membranes are made of two layers jointly known as the membrane bilayer. The docking step is mediated by snare proteins . They have a transmembrane that goes through the membrane bilayer and brings vesicles into close proximity with the plasma membrane. The snare proteins (located in the space between the membrane bilayer) make one membrane bilayer fuse with the other membrane bilayer and help fusion of vesicles occur. Synaptotagnin protein only functions in neurons. Synaptotagnin keeps snare proteins from aiding exocytosis of vesicles containing neurotransmitters until calcium is bound to synaptotagnin. When calcium binds to synaptotagnin, synaptotagnin is released from the snare proteins and the snare proteins aid in the fusion of the vesicles with the plasma membrane so that the neurotransmitters can be exocytosed into the synapse. Central and Peripheral Nervous System I want to discuss central nervous system and peripheral nervous system terminology and functions. Last lecture I talked about descending motor tracts, which originate in the cerebrum and transition through intermediate points called loci and track down the spinal cord to their respective destination. The two hemispheres are connected through the corpus callosum , which mediates communication across the two hemispheres. Crossover events in descending motor tracts occur
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This note was uploaded on 04/02/2008 for the course MCB 32 taught by Professor Wurmser during the Fall '07 term at University of California, Berkeley.

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7 - Molecular Cell Biology 32 Professor Andrew Wurmser...

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