Chemo Drug Categories.docx - Chemo Drug Categories Agents...

Chemo Drug Categories
 Agents that modify DNA stx
o Alkylating Agents
 Nitrogen Mustards
 Mechlorethamine
 Chlorambucil
 Cyclophosphamide
 Ifosfamide
 Melphalan
 Thiotepa
 Estramustine
 Others
 Nitrosoureas
 Carmustine
 Lomustine
 Streptozocin
 Procarbazine and Triazenes
 Procarbazine
 Dacarbazine
 Temozolomide
 Platinum Complexes
 Cisplatin
 Carboplatin
 Oxaliplatin
 Misc. Alkylating Agents
 Busulfan
 ABX
o Anthracyclines
 Daunorubicin
 Doxorubicin
 Epirubicin
 Valrubicin
 Idarubicin
o Mitoxantrone
o Bleomycin
 Topoisomerase inhibitors
o Camptothecins
 Irinotecan
 Topotecan
o Epipodophyllotoxins
 Etoposide
 Teniposide
o Anthracyclines (only partially – it’s not their main MOA)
 See above
 Antimetabolites
o Antifolates
 Methotrexate
o Pyrimidine Antagonists
 Pemetrexed
 5-Fluorouracil

 Capecitabine
o Purine Antagonists
 6-mercaptopurine
 6-thioguanine
o Nucleoside Analogues
 Cytarabine
 Gemcitabine
o Misc. Antimetabolites
 Pentostatin
 Hydroxyurea
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