4 CV electrophysiology 2019.pptx - Anatomy Physiology II Cardiac Electrophysiology Dr Heather Jones [email protected] 866-8133 Cardiac Cycle Diastole

4 CV electrophysiology 2019.pptx - Anatomy Physiology II...

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Anatomy & Physiology II: Cardiac Electrophysiology Dr. Heather Jones [email protected] 866-8133
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Cardiac Cycle Diastole : ventricular filling, muscle relaxed Systole : ventricular emptying, muscles contracted Electrical events signal contraction
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Cardiac Conduction Conduction System– electrical stimulation
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Pacemaker potential Sinus rhythm : firing of SA node, 70-80 bpm Pacemaker action potential – spontaneous firing Funny F- Type Na Funny current- pacemaker current Ca Transient K opens Ca long Ca closes L type Ca2+
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Pacemaker potential Autonomic regulation Parasympathetic: muscarinic activation increases K + channel conductance Sympathetic: 1 activation enhances I F and I ca through cAMP
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Conduction of Signal Electrical signal conducts through atria and to AV node 50 msec atrial myocytes depolarize 100 msec depolarization though AV node - slow 150 msec lapse between contraction of atria and ventricles
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Cardiac Myocyte Ventricular myocyte action potential
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Electrocardiograph ECG – detects and amplifies electrical signals of the heart Bipolar leads Tells us: 1. Size, location, damages 2. Effects of drugs
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Electrocardiograph ECG – clinical break: 7 Leads ECG Unipolar Leads and traces
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  • Spring '17
  • Cardiac electrophysiology, Sinoatrial node, ventricular tachycardia, Ventricular fibrillation, Cardiac Myocyte

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