PS2-08answ - Name: _ Section: _ TA: _ Problem Set 2...

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Name: ________________________ TA: __________________________ Section: _______________________ Problem Set 2 Biochemistry 462b Spring 2008 Due Feb 1, 2008 Research in metabolsim and metabolic regulation, unlike many other branches of biochemistry, often requires you to look at the whole organism. The pioneers of metabolic research studied bacteria and other single-celled organisms because they can be easily manipulated in the laboratory. Over the past two decades, "genetically engineered" mice (i.e. transgenic and knockouts) have become commonplace, allowing scientists who study metabolic regulation use these powerful model systems. Now, a biochemist interested in metabolism must be well-versed in both classical studies, such as the use of radio-labeled substrates, and modern genetic techniques. This problem set gives you the opportunity to consider both critical techniques. The following questions are based on the papers that will be presented during the discussion session on Thursday, Jan 31. Glucose transporter 4 (GLUT4) was identified by its similarity to another established glucose transporter whose function has already been validated. However, sequence similarity is not the same as biochemical function. GLUT4 is expressed in skeletal
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This homework help was uploaded on 04/02/2008 for the course BIOC 462b taught by Professor Grimes,tsao,borque during the Spring '08 term at University of Arizona- Tucson.

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PS2-08answ - Name: _ Section: _ TA: _ Problem Set 2...

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