4 - Science News As Cells Age The Nucleus Lets The Bad Guys...

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Science News / As Cells Age, The Nucleus Lets The Bad Guys In http://www.sciencenews.org/view/generic/id/40136/title/As_cells_a. .. 1 of 2 2/18/09 1:47 PM Home / News / News item By Laura Sanders Web edition : Thursday, January 22nd, 2009 http://www.sciencenews.org/view/generic/id/40136 AS CELLS AGE, THE NUCLEUS LETS THE BAD GUYS IN Stable pore proteins in nuclear membrane stick around but also weaken As cells get older, they don t lose their hair or teeth. Instead, they lose control over their nuclear membrane, the protective barrier that encases DNA in the nucleus, concludes a study published in the Jan. 23 Cell. This age-dependent leakiness may be closely tied to cell deterioration and age-related diseases such as Parkinson s and Alzheimer s, the new work suggests. “The implications of this study for our study of brain aging and for neurodegenerative diseases are potentially profound,” comments John Woulfe, a specialist in age-related diseases at the University of Ottawa in Canada. The new findings, he says, represent “an important step forward by bringing the
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4 - Science News As Cells Age The Nucleus Lets The Bad Guys...

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