HC.Wk11.Bb - Genetic Engineering: scientific background A...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Genetic Engineering: scientific background A gene is a sequence of DNA molecules that represents a unit of heredity; genes are located on chromosomes. We have 23 pairs of chromosomes 22 pairs of non- reproductive 1 pair of reproductive chromosomes
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What is Genetic Engineering? Genetic Engineering (GE) is the intervention at the level of genes. In GE, existing genes in a patient may be altered or new genes may be introduced. There are TWO important distinctions
Background image of page 2
1.Somatic Cell GE and Germ-line GE Somatic-cell GE involves alteration into non- reproductive cells e.g., blood cells Germ-line GE involves alterations into reproductive cells e.g., sperm or ova
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2. Therapeutic or non- Therapeutic GE Therapeutic GE or genetic therapy involves intervention aimed at curing disease Example: treating Huntington’s disease Non-therapeutic GE or enhancement engineering involves intervention at enhancement of human traits Example: improving memory, height
Background image of page 4
Terminology Moderate paternalism : extreme paternalism therapeutic GE : enhancement GE [preventing harm of disease v. providing beneficial traits] Somatic GE : germ cell GE you : your posterity [performed on non-reproductive or reproductive cells]
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Somatic cell therapy is relatively uncontroversial. (Principle of Beneficence) Germ-cell therapy more so. (Beneficence + efficiency) All enhancement is controversial.
Background image of page 6
Four Types of Genetic Intervention From the two distinctions, arise four types of genetic intervention: Somatic cell gene therapy (principle of beneficence) Somatic cell genetic enhancement Germ-line gene therapy (Beneficence + efficiency) Germ-line genetic enhancement (most controversial)
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Genetic Therapy or not? Why the various concerns about somatic – cell genetic therapy? Because it is experimental in nature. Myopia is not a good candidate for this therapy. Fanconi’s anemia is a serious genetic disorder of the bone marrow- clearly it is a good candidate for genetic therapy.
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Genetic Therapy and Enhancement There are many arguments against genetic enhancement Playing God (Designing Children) Goals of medicine, wealthy have an unfair advantage etc. Finding cures for deadly genetic disease is acceptable use of genetic intervention, but genetic enhancement is not.
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Walter Glannon on genetic therapy and enhancement Glannon argues that genetic intervention is acceptable only when it is directed at curing a disease; it is wrong if its purpose is the enhancement of traits (for instance, height, memory)
Background image of page 12
Moral argument against genetic enhancement 1. A just society provides equality of opportunity for all. 2. Normal health or well-being is necessary for obtaining equality of opportunity for all. 3. Therefore, a just society should aim to maintain
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 45

HC.Wk11.Bb - Genetic Engineering: scientific background A...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online