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11-8-07Linkages Notes

11-8-07Linkages Notes - Mechanisms that mix maternally...

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Mechanisms that mix maternally & paternally inherited chromosomes in gamete formation: -Independent assortment of chromosomes -Crossing over Independent assortment of chromosomes •Homologous pairs of chromosomes orient randomly - metaphase I •Homologous chromosomes (paternal and maternal) sort into daughter cells independently •Genes on different chromosomes are inherited independently And, crossing over mixes material on homologous chromosomes too •Prophase I: homologous chromosomes pair up gene by gene •DNA is swapped between homologous chromosomes •DNA from two parents combines into a single chromosome •Haploid cells do not contain just maternally inherited (red) or paternally inherited (blue) chromosomes •Individual chromosomes are mixed, and gamete cells have both maternally derived and paternally derived chromosomes Vocabulary Wild-type, mutant Parental type, recombinant Linked genes, sex linked, autosomal Barr body Duchenne muscular dystrophy, hemophilia, Aneuploidy, trisomic, monosomic, non-disjunction Down’s syndrome, Klinefelter’s syndrome, Turner’s syndrome Chapter 15, Figures 15.2, 3, 5
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CONCEPTS: 1. Linked genes are located near one another on the same chromosome and tend to be inherited together 2.
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