mid II review

mid II review - Midterm II review Replication Conservative...

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Replication Conservative vs semi-conservative Meselson-Stahl experiment Origin of replication, replication bubble bidirectional vs unidirectional RNA vs DNA synthesis Pol I, Pol III leading and lagging strand template, primer Okazaki fragments Enzymes: helicase, primase, single stranded binding protein, topoisomerase, ligase, sliding clamp Proofreading function; 3’-5’ exonuclease activity Primer removal: 5’-3’ Trombone model Telomeres, telomerase: aging, cancer Rolling circle replication Mutations and DNA repair Spontaneous mutations: replication errors, deamination, depurination DNA damage: ionizing radiation, carcinogens, UV light, DNA repair: translesion bypass, direct reversal, damage removal base excision repair, mismatch repair, nucleotide excision repair double strand break repair: non-homologous end joining and homologous recombination Restriction Enzymes methylase vs restriction enzyme primitive immune system
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This note was uploaded on 07/08/2009 for the course LIFESCI LS 3 taught by Professor Paulolague during the Fall '09 term at UCLA.

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mid II review - Midterm II review Replication Conservative...

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