LEC04a.ppt [Compatibility Mode]

LEC04a.ppt [Compatibility Mode] - RNA differs from DNA in...

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10/6/200 RNA differs from DNA in four basic respects Ribose instead of deoxyribose in the backbone (less stable in presence of alkali) Uracil instead thymine (5-methyl- uracil) Single stranded Secondary structure OH instead of H U instead of T
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10/6/200 RNA is less stable in alkali than DNA - The b kb backbone is broken
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10/6/200 Uracil is missing the 5-methyl group It has the same base-pairing properties as thymine RNA is primarily single-stranded with regions of secondary structure hairpin bulge Double stranded loop regions are in A form, not B form
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10/6/200 Base pairing can also occur between non- contiguous regions pseudoknots G:U pairs can also be found in RNA
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10/6/200 Additional noncanonical base pairs are also found Even triple base pairing is observed in RNA, helping stabilize many 3D structures
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10/6/200 Modified bases are found in some RNAs Some RNAs actually catalyze biochemical reactions
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10/6/200 tRNA structure (Fig. 4.5)
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10/6/200 RNAs can fold into structures which allow them to act like proteins Can act as scaffold to which proteins bind Be used as template for DNA synthesis (telomerase) Catalyze reactions Control gene expression Both RNA binding proteins and RNA chaperones help RNA fold correctly Fig 4.12
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10/6/200 RNAs involved in Cellular Processes RNP (RNA and protein) Process Role of RNA telomerase DNA replication Template for reverse transcriptase RNase MRP DNA replication and RNA processing Catalytic RNP Spliceosome RNA processing Catalytic RNA
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