LEC04a.ppt [Compatibility Mode]

LEC04a.ppt [Compatibility Mode] - RNA differs from DNA in...

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10/6/200 8 RNA differs from DNA in four basic respects Ribose instead of deoxyribose in the • Ribose instead of deoxyribose in the backbone (less stable in presence of alkali) • Uracil instead thymine (5-methyl- uracil) • Single stranded • Secondary structure OH instead of H U instead of T
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10/6/200 8 RNA is less stable in alkali than DNA - The b kb backbone is broken
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10/6/200 8 Uracil is missing the 5-methyl group It has the same base-pairing properties as thymine RNA is primarily single-stranded with regions of secondary structure hairpin bulge Double stranded loop Double stranded regions are in A form, not B form
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10/6/200 8 Base pairing can also occur between non- contiguous regions pseudoknots G:U pairs can also be found in RNA
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10/6/200 8 Additional noncanonical base pairs are also found Even triple base pairing is observed in RNA, helping stabilize many 3D structures
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10/6/200 8 Modified bases are found in some RNAs Some RNAs actually catalyze biochemical reactions
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10/6/200 8 tRNA structure (Fig. 4.5)
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10/6/200 8 RNAs can fold into structures which allow them to act like proteins • Can act as scaffold to which proteins bind • Be used as template for DNA synthesis (telomerase) • Catalyze reactions • Control gene expression Both RNA binding proteins and RNA proteins and RNA chaperones help RNA fold correctly Fig 4.12
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10/6/200 8 RNAs involved in Cellular Processes RNP (RNA and protein) Process Role of RNA telomerase DNA replication Template for reverse
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This note was uploaded on 07/08/2009 for the course LIFESCI LS 3 taught by Professor Paulolague during the Fall '09 term at UCLA.

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LEC04a.ppt [Compatibility Mode] - RNA differs from DNA in...

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