LEC06.PPT [Compatibility Mode]

LEC06.PPT [Compatibility Mode] - ! Enzymes...

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Unformatted text preview: ! Enzymes Structure/function Regulation ! Molecular Chaperones ! Antibodies Structure Structure Uses in Molecular Biology Protein Function Protein Function ! Function of a protein is determined by its 3D structure ! Changing as little as a single amino acid can be detrimental to protein structure and function ! Interactions between proteins and ligands are highly specific ! Binding affinity refers to the strength of the interaction between a ligand and a protein Enzymes are proteins that catalyze reactions Enzymes are proteins that catalyze reactions Substrates Substrates Products Products Enzyme Enzyme ! Substrates are converted to products with no overall change to the enzyme Substrates Substrates Products Products ! Enzymes speed up reactions by factors of 10 6 or more Terminology Terminology ! The name of an enzyme indicates its substrate or function. ! The suffix -ase is usually appended to the name: ! Protease ! Phosphatase ! Phosphatase ! Ribonuclease ! etc. Enzymes lower the energy needed for a Enzymes lower the energy needed for a reaction to proceed reaction to proceed ! Gibbs Free Energy (G) Gibbs Free Energy (G) is a measure of potential energy ! The American chemist Gibbs showed that all systems change in such a way that free energy is minimized ! For a chemical reaction: Reactants " Products ! G = G G = G products products- G reactants reactants Deamination of adenosine ! The transition state is generally represented by the intermediate of highest potential energy. Substrate Transition State Product ! Achievement of this activated state requires energy to cause a chemical bond to be strained or to excite electrons in the molecule....
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This note was uploaded on 07/08/2009 for the course LIFESCI LS 3 taught by Professor Paulolague during the Fall '09 term at UCLA.

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LEC06.PPT [Compatibility Mode] - ! Enzymes...

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