LEC13 - Midterm I Average Hi Lo A's B's C's 65 96 13 80-100...

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Midterm I ± Average: 65 ± Hi 96 ± Lo 13 ± A’s: 80-100 ± B’s: 60-79 ± C’s: 40-59
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Regrades ± Check exam with key online ± One week to turn in exam for regrades ± Write on front of exam which problem(s) you want regraded ± Turn it in to me. DNA Polymerase III DNA Polymerase III Holoenzyme Holoenzyme (E. coli) (E. coli) ± A complex of 17 polypeptides ± A multimeric protein containing two copies of the polymerase subunits ± Highly processive (can polymerize up to 500,000 nucleotides without falling off the template !)
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DNA polymerase accessory DNA polymerase accessory proteins proteins ± Sliding clamp protein ( β -subunit) ± forms a ring around DNA ± association with polymerase then prevents polymerase from dissociating from DNA
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3D structure of the 3D structure of the β -subunit subunit Additional Proteins required at the Additional Proteins required at the Replication Fork Replication Fork ± Helicase ± enzyme that catalyze the unwinding of double helix ± Single Stranded Binding proteins (SSB) ± stabilize single stranded DNA ± Topoisomerases ± catalyze the reversible breakage and rejoining of DNA strands, allowing the strands to rotate freely about one another
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Initiator DnaA Cdc6/Orc1 Helicase DnaB MCM Helicase loader DnaC (DnaA?) Cdc6/Orc1?
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This note was uploaded on 07/08/2009 for the course LIFESCI LS 3 taught by Professor Paulolague during the Fall '09 term at UCLA.

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LEC13 - Midterm I Average Hi Lo A's B's C's 65 96 13 80-100...

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