LEC14 - Announcements If you haven't picked up your exam,...

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Announcements ± If you haven’t picked up your exam, your TA should have it. ± One week for regrades ± Quiz 4: Due Monday noon Mutations: change in DNA sequence ± Positive: ± Provide genetic variation Æ drive evolution ± Negative: ± lead to heritable genetic disorders in germs cells; lead to aging, cancer or neurodegenerative disorders in somatic cells ± Genetic tool: ± used to characterize genes involved in cellular processes
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Mutations in coding regions can be classified into four different groups: Spontaneous Mutations ± Replication errors ± Deamination of C or A ± Depurination (hydrolysis of G or A)
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If replication errors are not corrected, they become permanent mutations. mismatch mutation Deamination of cytosine generates uracil (GC Æ GU) depurination leaves an abasic site However, deamination of 5-mC generates T, a natural base in DNA (not repaired as often)
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Mutagen ± Any chemical agent that causes an increase in the rate of mutation above the spontaneous level ±
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LEC14 - Announcements If you haven't picked up your exam,...

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