LEC23 - Studying Tips for Final: - Look at all lectures and...

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12/1/2008 1 Epigenetics C hanges in gene expression that are stably inherited, but are not due to changes in DNA changes in DNA sequence. Chromatin modifications can stably change gene expression Sometimes histone modifications sufficient Polycomb regulated genes H3K27 methylation Other times both DNA and histone modifications required Cytosine methylation H3K9 methylation
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12/1/2008 2 Polycomb regulation Antennapedia 1970s mutations were isolated that transformed one body part into another Homeotic mutations (eg fly legs grow instead of antennae) Named homeobox (hox) genes Regulated in part by Polycomb proteins
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12/1/2008 3 Hox genes are expressed in order and correlate with location in body of fly Conserved in mammals as well Encode transcription factors Polycomb regulation Named after another Drosophila mutant Complex of proteins that act through polycomb response element:PRE Represses transcription permanently (maintained through cell divisions): silencing
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12/1/2008 4 PRC2 is a complex of proteins which methylates H3K27 Polycomb Response Element PRC1 complex binds to the methylated K27 and inhibits transcription (mechanism unknown) Polycomb Response Element
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12/1/2008 5 Gene silencing through DNA methylation and H3K9 methylation Found commonly in heterochromatin Silence transposable elements Imprinted genes
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This note was uploaded on 07/08/2009 for the course LIFESCI LS 3 taught by Professor Paulolague during the Fall '09 term at UCLA.

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LEC23 - Studying Tips for Final: - Look at all lectures and...

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