LEC24 - Announcements Regrades due by Friday Office Hours...

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12/3/2008 1 Announcements Regrades due by Friday Office Hours: Today 2-3pm; Monday 1-2 pm Office Hours: Today, 2-3pm; Monday, 1-2 pm Final Exam: Tuesday 6:30-9:30 Moore 100: Janet, Diana, Ronika, Shawn, Gabriela, Allen La Kretz 110: Danny, Rachel, Jessica, Jennifer, Ana Marie PAB 1425: Lynn, Lauren, Courtney Genomics Genomics is the study of all the genes of a cell, or tissue, at the DNA (genome), mRNA (transcriptome), or protein (proteome) levels
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12/3/2008 2 DNA sequence of entire genomes First genome sequenced was a bacteriophage φχ 174 in 1977 by bacteriophage, 174, in 1977 by Frederick Sanger (invented DNA sequencing 5375 bp No introns, simple analysis revealed all di f open reading frames Start with ATG and end with stop codon Genes packed into small genome Φχ 174 genome From DNA sequence, all protein sequences can be deduced Surprising find: overlapping genes
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12/3/2008 3 Great reading over Xmas break
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12/3/2008 4 What have we learned from sequencing genomes?
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