final_exam_key_06

final_exam_key_06 - LS4.1 Final Exam 6110106 Your Name...

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Final Exam 6110106 LS4.1 Show AII Your Work for Full Credit. Your Name Circle your TA name 1 : Daphna student id# Lindsay May Shane section# f 2 P 3 P 4 f s f6 l 7 l 8 l e f r 0 Final Discussion Midterm I Midterm 2 Quizzes Grand Total
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Final Exam 6110106 Your Name Circle your TA name: Daphna Lindsay LS4.1 Show AII Your Work for Full Credit. student id# May Shane section# rT f 2 P 3 P 4 f s f6 f 7 l 8 l e f r 0 Final Discussion Midterm I Midterm 2 Quizzes Grand Total
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I. (20 points) Beginning with sequence l follow the directions below to show the steps needed to arrive. at the insertion sequence shown in 2. 4+ b. Make a sketch next to helix I to show the steps of what happens to the helix in I that leads to the helix in 2. Use a box to indicate the unknown transposable element in your sketch. Circle the nucleotides in the direct repeats of the target site DNA flanking the transposable element in helix 2.Thatwill indicate how many and which nucleotides. Put a box around and label the ATG initiation codon for the ORF inside the transposable element in helix 2. Do the same for the stop codon. Determine the transposable element regions that are repeated in helix 2. Indicate their Iocations and direction with an arrow underneath to show if they are direct or invprted repeats. what kind of transposable element are you annotating? F'l u ' /aCWt)*sf*% P+T ,L 1' *: o^Ho ,-,,c r+a6 ", TCCATTCCTATC -) T-<< Arrc<t J ATc ! ^ + + ' r ' h ' - ? n znt t !";h a?D ' 0 L ,"/'l-('^ 0-r^) ,4 a e TA fteQl , T4.1e e T4 c rcc +rTc q_l \TTCcMc ,'-.= ilik<l'i- ttLe ,7 / \ ....TT@GATCAGGnrcffi}rAG(on|yls t sno*nF-r - a. c. d.
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2. A. (12 pts) Jack and James are brothers who both have X linked recessive hemophila A. Their family has no prior examples of hemophilia so a new germ line mutation is suspected in their mother as her somatic DNA is unchanged. Examination of the DNA for the exons of the factor 8 gene in each brother gives results that are different from each other and from the normal. Jack James _.,,,. .-r) Why do these changes result in loss-of-function of the factor 8 gene? Jack -.(-{eS 213 James 3ataS event(s) that Ied to these products. Full credit for showing both origins from the same event(s). 2 3 4 .+ t ,,1,,g t 1 r r + 4 , I a ,2 rho4 2.8. (8 pts) A newborn with heart problems is referred to the genetics clinic as a suspected Down syndrome patient. FISH to interphase cells with a chromosome 2I probe reveals 3 dots. A microsatellite marker close to the chromosome 21 centromere was scored on DNA from both parents and patient, with the results shown below. What is your interpretation of the abnormality and its oriein? W
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3. (20 pts) You have been asked to advise Karl Landsteiner about the genetics of his discovery of the A and B blood group antigens. You have collected
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This note was uploaded on 07/08/2009 for the course LIFESCI ls 4 taught by Professor Merriam during the Winter '08 term at UCLA.

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final_exam_key_06 - LS4.1 Final Exam 6110106 Your Name...

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