week 8 1 - The CODIS loci D16S539 and D7S820 are GATA...

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The CODIS loci D16S539 and D7S820 are GATA repeats on a site on chromosome 16 and chromosome 7, respectively. There are many GATA repeat sites in the genome. How are the repeat numbers determined from one person s DNA specifically for D16S539 or D7S809? !"#$% ’()*+ ,+ -#. ,/#- 0% */,1*# 234 5$,6 #$ +#1*#/)# 1
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If one microsatellite is analyzed and found to have 20 different alleles (A, B, C, …, T), all having the same allele frequency, what is the chance that two individuals will both be DH? !"#$%&"#$%&(!"#$%&"#$%&)#$$$$!%*+,$$!%- 2
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A second site is examined, a microsatellite with 5 different alleles having the following frequencies: U-0.05; V-0.25; W- 0.50; X-0.10; Y-0.10. What is the chance two individuals are both VY at this second locus? 2(.25)(.10)x2(.25)(.10)=.0025 3
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What is a biallelic SNP? 7/’% 8 9’’#’#+ .($ :;# <=2 ’()*+ 4
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How many common biallelic SNPs exist in our genome? > 6 ,’’,(/ 5
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How can 1 common biallelic SNP assist in DNA forensics? ? )(6 6 (/ <=2 )(*’- ,/)$#9+# :;# (--+ 0% 90(*: 8 6
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How could 100 independent common biallelic SNPs assist in DNA forensics? @: ,/)$#9+#+ :;# (--+ 0% 90(*: 8 A ? B B 7
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Cri-du-chat (cry of the kitten) is a very serious disorder associated with loss of 1 copy of the tip of chromosome 5 short arm (5p-). Usually this is a new deletion mutant and is not repeated in another sibling; occasionally a family presents with several cases among the siblings. Chromosome analysis may show one parent with the tip of 5p translocated to the end of another chromosome (the parent is heterozygous for this rearrangement). • Draw a picture of this karyotype.
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This note was uploaded on 07/08/2009 for the course LIFESCI ls 4 taught by Professor Merriam during the Winter '08 term at UCLA.

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week 8 1 - The CODIS loci D16S539 and D7S820 are GATA...

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