Challenge problem 3 linkage

Challenge problem 3 linkage - 2,1 2,2 B,C 1,2 2,1 2,1 1,1...

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Challenge problem 3 linkage The location of the cystic fibrosis (CF) gene was further narrowed within the Met-D7S8 interval by means of mapping a rare crossover within this region from a family segregating the CF recessive trait. The genotypes of mother, father and several progeny are given below. The genotype of the mother’s father is added to help confirm phase of the markers for the CF mutant-bearing chromosome. Markers (in order) Met E6 H2 W30 Acc W32 Tc RV Mother’s genotype at each marker 2,1 2,2 2,1 B,A 1,1 2,2 2,1 1,2 mother’s father’s genotype 2,1 1,2 2,1 A,A 1,1 1,2 1,1 1,2 Father’s genotype 2,1 1,2 2,1 C,A 2,1 1,2 1,1 1,2 CHILD 1 (UNAFFECTED) 2,2
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Unformatted text preview: 2,1 2,2 B,C 1,2 2,1 2,1 1,1 CHILD 2 (UNAFFECTED) 2,1 2,2 2,1 B,A 1,1 2,2 2,1 1,2 CHILD 3 (AFFECTED) 1,1 2,2 1,1 A,C 1,2 2,1 1,1 2,1 CHILD 4 (AFFECTED) 1,1 2,2 1,1 A,A 1,1 2,2 1,1 2,2 a. Circle the marker alleles that are common between the mother and her father. What is the genotype of this chromosome? Do you see the same chromosome genotype in any other family member? b. Find the one crossover present in this family. How do you know this is a crossover? c. What is the most likely location of the CF gene? d. Using this information, determine which individuals in this pedigree are carriers for CF. Recall, both mother and father of the children have to be carriers....
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This note was uploaded on 07/08/2009 for the course LIFESCI ls 4 taught by Professor Merriam during the Winter '08 term at UCLA.

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