Section Handout #3

Section Handout #3 - e-mail [email protected] OH...

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e-mail: [email protected] OH: Tuesdays @4-5PM @ Roma BIPN 100 Hand-Out #3 ENDOCRINOLOGY Catecholamines Peptides Steroids (Cholesterol- based) Thyroid Source Adrenal medulla Lots Adrenal cortex, Reproductive organs Thyroid gland Solubility Water-soluble Water-soluble Lipid-soluble Lipid-soluble Receptor Type Membrane-bound Membrane-bound Intracellular Intracellular Response Time Shorter Shorter Longer Longer (Why shorter? Catecholamines and peptides bind to the extra- cellular matrix domain of G-protein-coupled membrane receptors, activating 2 nd messenger systems that modify pre-existing proteins) (Why longer? Steroids and thyroid hormones bind to intracellular receptors that modify gene transcription and therefore translation, and the effects don’t start until the mRNA are translated) Examples Dopamine, norepinephrine, epinephrine Insulin, glucagon, growth hormone, releasing hormones (from hypothalamus; a.k.a. trophic hormones) Testosterone, aldosterone, glucocorticoids (including cortisol) Thyroxins (2 hormones based on 2 linked tyrosine molecules) Anatomical Term Anterior Pituitary Posterior Pituitary Functional Term Adenohypophysis Neurohypophysis Hormones It Secretes FLAT PiG F SH (Follicle-Stimulating Hormone) L H (Luteinizing Hormone) A CTH (Adrenocorticotropic Hormone) T SH (Thyroid-Stimulating Hormone) P RL (Prolactin) i rrelevant G H (Growth Hormone) Oxytocin ADH (Antidiuretic Hormone; a.k.a. Vasopressin)
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Section Handout #3 - e-mail [email protected] OH...

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