2008 gene families and sensation

2008 gene families and sensation - Human genome 3 billion...

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Human genome • 3 billion bases • Average gene consists of 3000 bases • 30000 genes * 3000 bases= 9x 10 7 bases involved in coding proteins. • This implies substantial non coding regions • In addition, functions are unknown for over 50% of genes • 99.9% of genes are the same in all humans. • Implies that differences in expression of genes rather than genes themselves determine the differences in phenotype.
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Gene families: Temperature receptors
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DEG/ENaC channel superfamily: numerous functions related to mechanotransduction, proton sensing and ion transport
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Missing genes Altered genes Æ channelopathies • Genes can be important in development or function of sensory neurons • Dysfunctional genes in sensory neurons can lead to abnormal function (burning pain if nociceptive neurons become more active) • Missing genes can prevent function of sensory neurons • Missing genes can prevent sensory neuron development
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Dysfunctional nociception • Due to dysfunction of gene for NGF
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This note was uploaded on 07/15/2009 for the course BIO 208 taught by Professor Lorne-mendell,s during the Fall '08 term at SUNY Stony Brook.

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2008 gene families and sensation - Human genome 3 billion...

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