2008 Organization of the spinal cord and strategies for its repair

2008 Organization of the spinal cord and strategies for its repair

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Spinal Cord Injuries Spinal cord contusion (most common) Spinal transection Tumors Vascular accidents Spinal cord topography . Innervation of specific peripheral structures by specific segments determines the loss after injury Important targets close to injury site. Prevention of cell death close to lesion site and regeneration over short distances may have very beneficial effects. http://www.spinalinjury.net/html/_s pinal_cord_101.html
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Spinal cord is vulnerable to compression and injury from vertebral damage
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Spinal Cord Injury: More Than Axonal Damage • Contusion injury: weight drop • Cell death: excitotoxicity necrosis; apoptosis (neurons and oligodendrocytes (loss of ability to myelinate); release of immune, inflammatory mediators • Primary injury zone: due to contusion • Secondary injury zone: spreads from primary zone • Formation of cyst surrounded by scar: scar is impenetrable to growing axons unless broken down • Spared rim of white matter (axons) at the periphery of injury zone: target for recovery of function?
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Approaches to Spinal Cord Injury Top down (symptom) Reversal of functional deficits: * respiration * stepping * bladder/bowel * pain Bottom up (mechanism) Cellular/molecular mechanisms to be reversed or encouraged * inflammation * apoptosis/necrosis * changes in gene expression * axonal growth * synapse formation * activity related plasticity
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This note was uploaded on 07/15/2009 for the course BIO 208 taught by Professor Lorne-mendell,s during the Fall '08 term at SUNY Stony Brook.

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2008 Organization of the spinal cord and strategies for its repair

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