Class 10 Cortex Layers and Pathologies

Class 10 Cortex Layers and Pathologies - Cortical layering:...

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Cortical layering: development and 2 pathologies Class # 10 October 7, 2008
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Today’s outline General structure of layering in the cortex Development of cortical layers Examples in which these layers are disrupted: Dyslexia Prenatal effects of cocaine use on neonates
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Notes to me Bear et al Chap 23 Stem cells pg 693 CNS regeneration pg 705
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Quick overview of localization of function in the cortex
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Brain weight as a function of body weight Cell number increases by cell division As many as 250,000 cells added per minute Overproduction of cells which compete for trophic substances Cell death for the “losers”
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From Bruce Perry (Stanford University) MRI – Normal vs Global Sensory Neglect minimal exposure to language touch or social interactions.
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Frontal Occipital Circumference (FOC) is reduced to about the 10 percentile with Global Sensory Neglect
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Sensory deprivation neglect: effects of early removal on recovery. Children were removed from neglectful environments at different ages (ages 8 months to 5.7 years). Their frontal- occipital circumference was measured and compared to same-aged norms (blue bars). Children were placed in foster care and one year later re-evaluated. FOC was measured (maroon bars) and in each group increased although with increasing age, the improvement after a year of foster placement started to decrease such that children removed after four years in the neglectful setting had no improvement one year later. Data are from 112 children with some form of severe neglect in the first five years of life (modified from Perry and Pollard, 1997).
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The cerebral cortex is highly layered
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Cortical areas differ in detail, but basic organization is the same.
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Histogenesis of the cerebral cortex - At first there are 3 zones to the cortex: 1) germinal zone , immediately surrounding the lateral ventricle, 2)
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This note was uploaded on 07/15/2009 for the course BIO 208 taught by Professor Lorne-mendell,s during the Fall '08 term at SUNY Stony Brook.

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Class 10 Cortex Layers and Pathologies - Cortical layering:...

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