Class 16 Designer drug upload

Class 16 Designer drug upload - So you think natural is...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
So you think natural is better? Evolution of designer drugs. Lecture 16 October 30, 2008
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Outline Overview of plants and use for medicines Ergot poisoning and migraine Opium and endorphins Aspirin to Vioxx
Background image of page 2
Plants and medicine Plants only make chemicals to ensure their own survival: Attractants and/or repellents Use for humans is purely incidental as plants were here before we were Fungus on rye – to – ergotamine Willow bark – to – aspirin Coca leaves – to – cocaine Yew leaves – to – taxol Bark of a Peruvian tree – to – quinine
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Ergot alkaloids Product of fungus that grows on rye Spores penetrate grain; purple nodule USDA will reject crop if >0.3% infected Rejection rate from 1 – 36% of crop Ergot poisoning known for over 2700 yr Causes stillbirth, death of mother, Burning and gangrene in extremities Holy fire; St. Anthony’s fire
Background image of page 4
http://www.botany.hawaii.edu/faculty/wong/BOT135/LECT12.HTM For more on the history of ergot see below link.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Ergots – medical uses 16 th century – used by midwives 19 th century – used in US induce to labor, discontinued because of high mortality. control postpartum hemorrhage Not used in Europe because of long history of Ergot poisoning. Ergonovine used to treat postpartum hemmorrage Ergotamine used to treat migraines
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Affects all known dopamine, serotonin and norepinephrine receptors Causes peripheral vasoconstriction Stimulates Uterine muscle contraction Depresses blood pressure control centers Problem was to separate components of Problem was to separate components of Ergots that would have specific targets for Ergots that would have specific targets for therapeutic uses. therapeutic uses.
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 36

Class 16 Designer drug upload - So you think natural is...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online